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Year : 1979  |  Volume : 11  |  Issue : 3  |  Page : 201-208

Evidence for the indirect effect of histamine in the estrogen primed rat uterus

Correspondence Address:
S C Verma

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Source of Support: None, Conflict of Interest: None

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. Histamine and 4-methylhistamine (4-MH), a specific H2-receptor agonist produced dose related relaxation of uterine strips obtained from estrogen primed rats, while 2-(2-pyridyl) ethylamine (PEA), a specific H,-receptor agonist had no significant effect. Metiamide, the specific H2-receptor antagonist inhibited the responses to histamine and 4-MH, while mepyramine maleate, the specific H1- receptor antagonist did not produce any significant effect. Propranolol, the classical adrenergic beta-receptor antagonist also inhibited histamine and 4.MH induced relaxation of the estrogen primed rat uterus. Reserpine pretreatment (5 mg/kg) significantly reduced the histamine and 4-MH responses. Our findings suggest that histamine acts indirectly on the uterus to produce inhibition by stimulating H. receptors. H1-receptors do not appear to be present in the rat uterus.


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