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Year : 1979  |  Volume : 11  |  Issue : 3  |  Page : 189-194

Effect of dehydroemetine on adrenergic synapses of rat vas deferens

Correspondence Address:
D S Shah

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Source of Support: None, Conflict of Interest: None

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Dehydroemetine (DHE) caused a reversible blockade of contractile responses due to field stimulation of vas deferens preparation of rat. Unlike other adrenergic neurone blockers such as guanethidine, dextroamphetamine did not prevent the neurone blocking action of DHE and the responses of exogenously added norepinephrine (NE) were antagonised by DHE. The responses due to 5-hydroxytryptamine (5-HT) and KC1 were antagonised noncompetitively by several concentrations of DHE (1.8 x 10-5 M, 3.6 x 10-5M and 7.2 x 10-5M). The computation of pD2 values of different concentration of DHE suggested a common site of action. 3.6 x 10-5 M of DHE, which showed noncompetitive antagonism against all the three agonists NE, 5-HT and KC1 antagonised the Cacl2 , induced contractible responses in depolarised preparations competitively. It is concluded that DHE exerts a nonspecific antagonistic action by interfering with exitation-contration coupling mechanism and its neurone blocking effect does not resemble that of a classical neurone blocker such as guanethidine.


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