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Year : 1979  |  Volume : 11  |  Issue : 3  |  Page : 177-180

Depletion of noradrenaline in the rat brain by histamine

Correspondence Address:
N Subramanian

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Source of Support: None, Conflict of Interest: None

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. Histamine depletes the noradrenaline levels in different regions of rat brain when administered intracisternally. A decrease in the catecholamine level could also be effected by 2-(2-pyridyl) ethylamine (H1-agonist) and compound 48 / 80 (histamine releaser) or following histidine loads to the animals.This decrease in noradrenaline levels could not be observed if the animals are pretreated with H1-antagonists. The results, in conjunction with the in vitro data documented, suggest the cerebral effects of histamine are at least in part mediated by modulation of the noradrenergic processes.


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