| RESEARCH PAPER |
|
| Year : 1979 | Volume
: 11
| Issue : 3 | Page : 177-180 |
Depletion of noradrenaline in the rat brain by histamine
N Subramanian
Correspondence Address:
N Subramanian
 Source of Support: None, Conflict of Interest: None  | Check |
.
Histamine depletes the noradrenaline levels in different regions of rat brain when administered intracisternally. A decrease in the catecholamine level could also be effected by 2-(2-pyridyl) ethylamine (H1-agonist) and compound 48 / 80 (histamine releaser) or following histidine loads to the animals.This decrease in noradrenaline levels could not be observed if the animals are pretreated with H1-antagonists. The results, in conjunction with the in vitro data documented, suggest the cerebral effects of histamine are at least in part mediated by modulation of the noradrenergic processes.
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