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Year : 1979  |  Volume : 11  |  Issue : 3  |  Page : 167-168

Dr. B. Mukerji – reminiscences

Correspondence Address:
Aiman Ranita

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Source of Support: None, Conflict of Interest: None

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. The effect of bacterial endotoxin (TAB vaccine and Shigella dysenteriae somatic type 0 antigen) and the prostaglandins (PCs) has been studied on the cloacaI temperature of unanaesthetized pigeons. The endotoxin produced hypothermia which showed little dose dependance and which w as more marked after intravenous than after intracerebroventricular injection and a very delayed hyperthermia brought in relief by the circadian rhythm of the body temperature. The PGs E1 E2 F1and F2 were devoid of temperature effect when injected intraventricularly at ambient temperature between 10(-30(C. Injected intravenously, PGE, produced a small hypothermia. Intravenous injection of indomethacin, an inhibitor of PG synthesis, neither affected the normal temperature nor modified the endotoxin hypothermia. It is inferred that PGs are not involved in themoregulation and the early hypothetic effect of the endotoxin may be due to its direct action on the skin blood vessels.


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