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Year : 1979  |  Volume : 11  |  Issue : 2  |  Page : 143-146

Inhibitory effect of thiabendazole on isolated guinea pig ileum against different agonists

Correspondence Address:
Pillai N Padmanabha

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Source of Support: None, Conflict of Interest: None

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. Thiabendazole when incubated (in vitro) for 5 min produced a dose dependent inhibition of Ach responses in guineapig isolated ileum preparation. In lower concentrations (500 ng) the inhibition produced by thiabendazole is relatively specific to histamine and acetylcholine, whereas in higher concentration (5 (g) a nonspecific inhibition of the responses of histamine, ACh. 5-hydroxytryptamine and potassium chloride was observed.


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