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Year : 1979  |  Volume : 11  |  Issue : 2  |  Page : 113-118

In vitro effects of cyclic AMP, L-dopa and 6-hydroxydopamine on rat brain dopamine - beta - hydroxylase

Correspondence Address:
Srivastava Madhulika

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Source of Support: None, Conflict of Interest: None

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. Dopamine-f-hydroxylase (DBH activity of rat brain was found to be stimulated by cyclic tand L- DOPA. The stimulation of enzyme activity increased with increasing concentration of the activators. 6 -hydroxydopamine (6-OHDA) caused an inhibition of brain DBH activity which may be due to the degeneration of adrenergic neurons. .The inhibitory effect was partially prevented in presence of cAMP or GDOPA.


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