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Year : 1978  |  Volume : 10  |  Issue : 4  |  Page : 327-328

Quantum Pharmacology

Correspondence Address:
W G Richards

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Source of Support: None, Conflict of Interest: None

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. Dichlorvos (2-2-dichlorovinyl dimethyl phosphate), an organic phosphate insecticide, has been tested for its acute and subacute oral toxicity in White Leghorn male chicks. LD50 values calculated by the graphic method of Litchfield and Wilcoxon was 6.45 mg per kg with 5.10 and 8.06 as 95% confidence limits. Seven-day old chicks could not tolerate levels of 500 ppm (0.05%) of dichlorvos in the diet and responded by weight loss and mortality.There was a significant depression of brain cholinesterase activity in all the treated groups fed with 50, 100 and 500 ppm of dichlorvos.


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