IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 2957 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded82    
    Comments [Add]    

Recommend this journal


Year : 1978  |  Volume : 10  |  Issue : 4  |  Page : 319-322

A convenient method for evaluation of dermal irritant effect on rabbits

Correspondence Address:
R K Srivastava

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

. A convenient method has been evolved to assess the dermal irritant effect of drugs and chemicals with low level of irritancy in conscious and unrestrained rabbits. Selected areas on either flank of rabbits were closely shaven and were painted with 20% formalin as primary irritant. Subsequently, pieces of cotton lint impregnated with the solutions of the test compounds encased in 'pill boxes' were placed in contact with the skin and 0.25 ml of a 0.5% sterile solution of Evans blue was injected intravenously. Intensity of blue colour developed in the treated areas was taken as the index of degree of dermal irritancy.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow