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Year : 1978  |  Volume : 10  |  Issue : 3  |  Page : 221-225

Effects of concurrent use of benzodiazepines and anticholinergics on the safety index of ether and halothane in mice

Correspondence Address:
J L Goel

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Source of Support: None, Conflict of Interest: None

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. Safety index of ether and halothane was determined in mice pretreated with chlordiazepoxide, diazepam, flurazepam, nitrazepam and oxazepam administered alone or in combination with atropine or hyoscine. Chlordiazepoxide, nitrazepam and oxazepam raised the safety index of ether. Atropine or hyoscine combination did not affect their safety index raising activity.The safety index of halothane was raised by diazepam, nitrazepam and oxazepam when given alone and was unaffected by combination of these premedicants with atropine or hyoscine.


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