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Year : 1978  |  Volume : 10  |  Issue : 3  |  Page : 215-220

Mechanism of adrenergic potentiation by a substituted propiophenone, U-0882

Correspondence Address:
K P Gupta

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Source of Support: None, Conflict of Interest: None

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. ( -phenoxy- ( dimethyl aminomethyl propiophenone (U-0882) has been found to potentiate sympathetic nerve stimulation and catecholamine responses on spinal cat's blood pressure. Nictitating membrane and isolated rat vas deferens preparation. The adrenergic potentiation is not due to inhibition of the enzyme catechol-o-methyl transferase or blockade of the catecholamine reuptake mechanism or decentralisation. It appears that adrenergic potentiation by U-0882 is due to direct sensitisation of the adrenergic receptors.


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