| RESEARCH PAPER
|Year : 1978 | Volume
| Issue : 3 | Page : 185-190
Effect of chlorpromazine on salmonella antibody synthesis in man
KC Singhal, R Kumar, Singhal Usha
Forty healthy individuals and 70 psychiatric patients aged 25 to 45 years without previous history of TAB inoculation or enteric fever during last one year and serum negative for S. typhi and S. paratyphi (A & B) antibodies (titre<40) were selected. Group of 40 healthy individuals served as control. The psychiatric patients were started on chlorpromazine 2.5 mg three times a day orally. On 7th day 1 ml of formalised TAB vaccine (Glaxo) was injected subcutaneously. Blood was with-drawn on 15th and 30th days of inoculation and serum was tested for antibody titre by agglutination. The antibody titre was significantly lower in the chlorpromazine treated group against TO and TH on 15th day and against PA (H) and PB (H) also on 30th day. The parallel shift of the curves in the treated group as compared to the control suggests that only one mechanism is likely to be responsible for the reduction in antibody titre. It is concluded that chlorpromazine produces a significant immunological inhibition when administered for 7 days prior to TAB vaccine.
K C Singhal
Source of Support: None, Conflict of Interest: None