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Year : 1978  |  Volume : 10  |  Issue : 2  |  Page : 171-173

Effect of cyproheptadine on ascorbic acid uptake by bone in vitro

Correspondence Address:
S L Sarkar

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Source of Support: None, Conflict of Interest: None

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. Ascorbic acid uptake of homogenised long bone of rats was estimated after 21/2h incubation in Ringer phosphate bicarbonate buffer (pH 7.4) containing 0,1,25,50,100,200 ng/ml cyproheptadine. In a similar experiment, ascorbic acid uptake was estimated in the presence of 25 ng/ml serotonin and a combination of 25 ng/ml each of serotonin and eyproheptadine. Cyproheptadine 25, 50 and 100 ng/ml significantly increased ascorbic acid uptake. while with 200 ng/ml the uptake was significantly reduced. Although serotonin per se did not affect the uptake of ascorbic acid, it inhibited cyproheptadine induced increase in ascorbic acid uptake.


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