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Year : 1978  |  Volume : 10  |  Issue : 2  |  Page : 167-169

Phenformin on blood lactate in dogs

Correspondence Address:
R B Patel

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Source of Support: None, Conflict of Interest: None

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. Administration of phenformin 10-20 mg/kg, chlorpropamide 20 mg/kg and their combination 10 mg/kg and 20 mg/kg respectively p.o. daily to normal dogs for 12 weeks were studied for the. effect on resting blood lactic acid level. Phenformine 10 mg/kg daily either alone or in combination with chlorpropamide does not increase the blood lactate level. Administration of a high dose (50 mg/kg) of phenformin in a slow i.v. drip for 4 consecutive days to normal healthy dogs does not induce hyperlactacidaemia.


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