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Year : 1978  |  Volume : 10  |  Issue : 2  |  Page : 163-166

Antifilarial activity of mebendazole against Setaria cervi

Correspondence Address:
K C Singhal

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Source of Support: None, Conflict of Interest: None

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. Mebendazole administered orally upto a dose of 500 mg/kg was ineffective either in eradicating microfilariae from the peripheral circulation of rats infected with Setaria cervi or in affecting the implanted adult worms. The lack of effect of mebendazole is likely due to its low absorption from the alimentary tract. Mebendazole was also ineffective in reducing the survival time of microfilariae in vitro. Mebendazole in low doses produced stimulation of the movements of adult worm and nerve-muscle complex which was not blocked by prior addition of d-tubocurarine. This suggests that acetyl-choline is not involved in bringing about the stimulant effect. At higher concentrations, the drug caused complete irreversible paralysis of the whole worm as well as the nerve-muscle complex of S. cervi. The dose required to produce an equivalent effect in the nerve-muscle complex was 1/10th of that required for the whole worm suggesting the existence of a cuticular barrier.


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