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Year : 1978  |  Volume : 10  |  Issue : 2  |  Page : 135-138

Hypercholesterolemic effect of angiotensin

Correspondence Address:
K N Singh

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Source of Support: None, Conflict of Interest: None

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. Angiotensin II administered i.c.v. resulted in a significant increase in blood cholesterol level in dogs. The hypercholesterolemic effect of angiotensin was not observed in bilaterally vagotomized or in hepatectomized dogs. It is suggested that centrally administered angiotensin exerts its effect on liver through vague. It is possible that i.c.v. administration of angiotensin inhibits the vagal centre in the CNS which brings about an increase in blood cholesterol level.


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