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Year : 1978  |  Volume : 10  |  Issue : 1  |  Page : 35-39

Analgesic and anti-inflammatory effects of tranylcypromine and imipramine

Correspondence Address:
A K Gupta

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Source of Support: None, Conflict of Interest: None

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. Analgesic activities of the MAO inhibitor tranylcypromine (TCP) and tricyclic antidepressant imipramine (IMP) were investigated in mice by hot plate, tail clip and bradykinin induced writhing tests. Pretreatment with TCP IO mg/kg i.p. (4h) and IMP 40 mg/kg i.p. (l/2 h) marginally raised the hot plate reaction time but markedly potentiated the morphine analgesia. They also effectively raised the reaction time in the tail clip test. In the bradykinin induced writhing test both TCP and IMP proved to be effective even in l/4 th the doses. When tested for anti-inflammatoty activities in rats TCP 2.5 mg/kg i.p. and IMP 10 mg/kg i.p. inhibited the carrageenin-induced hind paw oedema and in the same doses their daily administration for 7 days inhibited the cotton pellet granuloma.


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