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Year : 1978  |  Volume : 10  |  Issue : 1  |  Page : 21-25

Effect of some nonsteroidal anti-inflammatory agents on IUCD induced inflammation

Correspondence Address:
K Srivastava

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Source of Support: None, Conflict of Interest: None

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. Insertion of a silk thread as intrauterine contraceptive device (IUCD) into one horn of the rat uterus produced hypertrophy, cystic glandular hyperplasia, localized keratinized squamous metaplasia and release of polymorphs in the lumen of IUCD containing horn. These changes were partially prevented by the administration of two nonsteroidal anti-inflammatory drugs, the curcumin (diferuloyl methane, CDRI) and oxyphenbutazone at the dose of 30 mg/kg and 20 mg/kg respectively.


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