| RESEARCH PAPER |
|
| Year : 1977 | Volume
: 9
| Issue : 4 | Page : 301-304 |
A possible involvement of presynaptic receptors in action of apomorphine and clonidine in open field situation
PC Dandiya, RC Chowdhri, OP Mangal
Correspondence Address:
P C Dandiya
 Source of Support: None, Conflict of Interest: None  | Check |
Both clonidine and apomorphine lowered the open field performance of albino rats. Both when given individually along with antiparkinsonian agents like I-DOPA. benztropine and d -amphetamine lowered the open field scores of these antiparkinsonian agents. The parallel effects of apomorphine and clonidine suggest a common mechanism for their action i.e. stimulation of prarynaptic dopamine and/or norepinephrine receptors in CNS which regulate synthesis and release of DA and/or NE.
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