| RESEARCH PAPER
|Year : 1977 | Volume
| Issue : 4 | Page : 301-304
A possible involvement of presynaptic receptors in action of apomorphine and clonidine in open field situation
PC Dandiya, RC Chowdhri, OP Mangal
Both clonidine and apomorphine lowered the open field performance of albino rats. Both when given individually along with antiparkinsonian agents like I-DOPA. benztropine and d -amphetamine lowered the open field scores of these antiparkinsonian agents. The parallel effects of apomorphine and clonidine suggest a common mechanism for their action i.e. stimulation of prarynaptic dopamine and/or norepinephrine receptors in CNS which regulate synthesis and release of DA and/or NE.
P C Dandiya
Source of Support: None, Conflict of Interest: None