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 RESEARCH PAPER
Year : 1977  |  Volume : 9  |  Issue : 4  |  Page : 301-304

A possible involvement of presynaptic receptors in action of apomorphine and clonidine in open field situation



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P C Dandiya


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Both clonidine and apomorphine lowered the open field performance of albino rats. Both when given individually along with antiparkinsonian agents like I-DOPA. benztropine and d -amphetamine lowered the open field scores of these antiparkinsonian agents. The parallel effects of apomorphine and clonidine suggest a common mechanism for their action i.e. stimulation of prarynaptic dopamine and/or norepinephrine receptors in CNS which regulate synthesis and release of DA and/or NE.






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