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Year : 1977  |  Volume : 9  |  Issue : 4  |  Page : 295-300

A study on the tyramine induced outflow of 3H-norepinephrine and its metabolic pattern in rat vas deferens

Correspondence Address:
J Jayasundar

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The pattern of spontaneous end tyramine-induced outflow of 3H-norepinephrine (3HNE) end its metabolites in rat isolated vas deferens was evaluated. The tritium content of spontaneous outflow. obtained prior to the addition of tyramine, was found to be consistent. This outflow consisted of unchanged 3H-NE (27.9%) and its metabolites mainly, DOPEG (32.3%) and MOPEG (18.5%). Tyramine (2 x10-5 g/ml) caused a 10 fold increase over the spontaneous outflow of tritium. This increased outflow contained higher proportion of unchanged 3H-NE (68%) with DOPEG (12.1 %) and MOPEG (8.5%) as the major metabolites. The tissues prior to the addition of tyramine contained almost all the tritium in the form of unchanged 3H-NE. These findings suggest that only after 3H-NE has been released from its storage sites. It is metabolised. Also these results revealed that in rat vas deferens, 3H-NE is preferentially metabolised into two glycol derivatives i.e. DOPEG and MOPEG.


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