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Year : 1977  |  Volume : 9  |  Issue : 4  |  Page : 291-294

Investigations on the effect of chlorpropamide on release of antidiuretic hormone

Correspondence Address:
Kulshreshta Shoba

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The antidiuretic effect of chlorpropamide was investigated in the present study. Bioassay of ADH was done in the dog's serum after administering hypotonic saline, 2% alcohol and chlorpropamide. The nature of the chlorpropamide induced antidiuretic response w a s investigated and for this purpose sodium thioglycollate inactivation of ADH activity was done. In normal serum, 64.12% activity of ADH was lost by incubation with sodium thioglycollate. In case of serum after treating with chlorpropamide the loss of ADH like activity was only in the order of 46.35%. The antidiuretic response produced by serum after chlorpropamide to dogs is largely due to the drug itself and not due to ADH. This study shows that chlorpropamide produces an antidiuretic effect of its own and not through the facilitated release of ADH.


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