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 RESEARCH PAPER
Year : 1977  |  Volume : 9  |  Issue : 4  |  Page : 285-289

Hyperglycaemic effect of angiotensin



Correspondence Address:
K N Singh


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Intracerebroventricular administration of angiotensin (10 (g) caused a rise in blood glucose level in rabbits. The hyperglycaemia was not affected by bilateral vagotomy and was less marked in adrenalectomized rabbits. The hyperglycaemic effect was not observed in reserpinized and spinal vagotomized rabbits. It is suggested that intracerebroventricular administration of angiotensin stimulates the hypothalamic or medullary accelerator neurons (central sympathetic structures) to cause a marked release of catecholamines from peripheral stores specially adrenal medulla. This excessive release of catecholamines is responsible for hyperglyoaemia induced by angiotensin-II in rabbits.






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