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Year : 1977  |  Volume : 9  |  Issue : 4  |  Page : 273-277

Cardiovascular and other pharmacological actions of ketamine

Correspondence Address:
Rao P Prabhakar

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Source of Support: None, Conflict of Interest: None

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Cardiovascular effects of ketamine (KT) were studied in dogs in varying doses upto 20 mg/kg body weight. KT when administered intravenously in small doses produced a transient rise in blood pressure and subsequently a fall in blood pressure was observed with a dose of 10 mg/kg and above, The transient rise in blood pressure might be due to the release of catecholamines. KT is a relaxant to the plain muscle, mainly intestines and peripheral vasculature. It is a mild analgesic agent when compared to pethidine and morphine. KT raises the body temperature in rabbits by about 1° C.


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Online since 20th July '04
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