| RESEARCH PAPER
|Year : 1977 | Volume
| Issue : 4 | Page : 273-277
Cardiovascular and other pharmacological actions of ketamine
Rao P Prabhakar, VSV Subbu
Cardiovascular effects of ketamine (KT) were studied in dogs in varying doses upto 20 mg/kg body weight. KT when administered intravenously in small doses produced a transient rise in blood pressure and subsequently a fall in blood pressure was observed with a dose of 10 mg/kg and above, The transient rise in blood pressure might be due to the release of catecholamines. KT is a relaxant to the plain muscle, mainly intestines and peripheral vasculature. It is a mild analgesic agent when compared to pethidine and morphine. KT raises the body temperature in rabbits by about 1° C.
Rao P Prabhakar
Source of Support: None, Conflict of Interest: None