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Year : 1977  |  Volume : 9  |  Issue : 4  |  Page : 259-264

Phenothiazines as histamine and serotonin antagonists without sedation: Part II

Correspondence Address:
Singh Vijai

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Source of Support: None, Conflict of Interest: None

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A series of 10-N-acylamino phenothaizines posse-sing N-(-hydroxyethyl piperazine moiety in their side chain showed antihistaminic, antispasmodic and antiserotoninergic activity. On comparison with promethazine HCI, diphenhydramine HCI and cyproheptadine HCI, the compounds of this series were found feeble in potency but less toxic. All the test compounds were devoid of central nervous system depressant activity.


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