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Year : 1977  |  Volume : 9  |  Issue : 4  |  Page : 253-258

A Comparative trial of some commonly used hypnotics in normal subjects

Correspondence Address:
T Joseph

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Source of Support: None, Conflict of Interest: None

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An attempt has been made to assess under double blind trial, the hypnotic potency of five commonly used hypnotics, in the face of a rapidly filling bladder. All drugs significantly prolonged sleep interval and increased depth of sleep when compared to placebo. When drugs were compared in pairs. there was no significant difference between them except that methaqualone diphenhydramine combination significantly prolonged sleep interval when compared to seconol sodium. The incidence of drowsiness was significant with diphenhydramine (P <0.02) and the occurrence of dreams was very significant with nitrazepum (P <0.001). Head-ache, heaviness of head and dizziness was complained of with methaqualone-diphenhydramine combination (P <0.02). There was no correlation between volume of urine on awakening and sleep interval.


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