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Year : 1977  |  Volume : 9  |  Issue : 3  |  Page : 207-210

Effect of intravenous administration of frusemide on the blood sugar and alloxan diabetic rabbits

Correspondence Address:
K U Ansari

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Intravenous administration of frusemide in rabbit produced hyperglycemia. Administration of 26 mg/kg produced mild, transient non-significant hyperglycemia in normal rabbits but in alloxan treated rabbits marked hyperglycemia of long duration was observed with the same dose. However, in normal rabbit frusemide administered in the dose of 250 mg/kg for 3 consecutive days produced a state resembling clinical diabetes mellitus persisting for one month or even more. The significance of the findings is discussed.


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