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Year : 1977  |  Volume : 9  |  Issue : 3  |  Page : 203-206

Pressor response to antihistaminics in chicken

Correspondence Address:
S S Yadav

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Source of Support: None, Conflict of Interest: None

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Promethazine hydrochloride and diphenhydramine hydrochloride, showed a marked and sustained rise in blood pressor in phenobarbitone anaesthetized WLH chickens which is contrary to the effects in mammals. Pressor effect was not blocked by alpha or beta adrenergic receptor blocking agents. Pretreatment with two doses each of alphamethyl-para-tyrosine and reserpine did not affect the pressor effect of antihistamines. However birds pm-treated with higher doses of reserpine (10 mg/kg daily for two days) showed a marked decrease in pressor response to promethazine. The findings suggest that the pressor response to antihistaminics in chicken is probably mediated through the release of catecholamines.


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