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Year : 1977  |  Volume : 9  |  Issue : 3  |  Page : 189-194

Studies on anti-asthmatic and anti-anaphylactic activity of Albizzia lebbeck

Correspondence Address:
R M Tripathi

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The effects of the decoction of the bark and flower of Albizzia lebbeck were studied for its anti-asthimatic and anti-anaphylactic activity. The decoctions protected the guinea pig against histamine as well as acetylcholine induced broncho-spasm. Chronic treatment with the bark decoction has also protected the sensitized guinea pigs against antigen challenge. However, the drug has no significant effect on the rat mesenteric mast cell count and has not protected the mast cell from the disruption induced by compound 48/80. The drug inhibited the rate of disruption of mast cells induced by antigen in sensitized albino rats. It has no effect on the adrenal. thymus and spleen weight as well as adrenal ascorbic acid but the cholesterol content was significantly reduced. The antiasthmatic and antianaphylactic actvities of the drug cannot be wholly due to smooth muscle relaxant, antihistamine or antispasmodic activity nor are mediated through stability of mast cells or adrenal gland. The effect seems to be due to inhibition of phenomenon of sensitisation.


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