IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1153 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded81    
    Comments [Add]    

Recommend this journal


Year : 1977  |  Volume : 9  |  Issue : 2  |  Page : 141-146

A possible mechanism of reserpine induced emesis in pigeons

Correspondence Address:
P C Dandiya

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Reserpine induced emesis which has been ascribed to increased parasympathetic tone, remained uninhibited by drugs like atropine. haloperidol and pimozide. Chlorpromazine failed to block this emesis suggesting that reserpine did not act by stimulating the rudimentary chemoreceptor trigger zone in pigeons. Apomorphine failed to induce emesis in these birds. Cyclizine in low doses blocked the emetic response. although in higher doses it itself induced such an emetic response and also potentiated this response due to reserpine. Bilateral vagotomy at the carotid level failed to block the emesis. Histological studies indicate desquamation of epithelial cells induced by reserpine. Reserpine induced emesis appears to be mediated by dopaminergic, serotonergic and hormonal factors.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow