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 RESEARCH PAPER
Year : 1977  |  Volume : 9  |  Issue : 2  |  Page : 141-146

A possible mechanism of reserpine induced emesis in pigeons



Correspondence Address:
P C Dandiya


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Reserpine induced emesis which has been ascribed to increased parasympathetic tone, remained uninhibited by drugs like atropine. haloperidol and pimozide. Chlorpromazine failed to block this emesis suggesting that reserpine did not act by stimulating the rudimentary chemoreceptor trigger zone in pigeons. Apomorphine failed to induce emesis in these birds. Cyclizine in low doses blocked the emetic response. although in higher doses it itself induced such an emetic response and also potentiated this response due to reserpine. Bilateral vagotomy at the carotid level failed to block the emesis. Histological studies indicate desquamation of epithelial cells induced by reserpine. Reserpine induced emesis appears to be mediated by dopaminergic, serotonergic and hormonal factors.






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