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Year : 1977  |  Volume : 9  |  Issue : 1  |  Page : 11-16

Importance of plasma serotonin in intestinal obstruction

Correspondence Address:
C N Prasad

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Source of Support: None, Conflict of Interest: None

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The role and importance of Serotonin in intestinal obstruction has been evaluated by studying 40 cases of intestinal obstruction of varying etiology. The plasma level of Serotonin had been significantly higher in acute mechanical obstructions particularly when small bowel is obstructed primarily: the fall in the plasma level, following relief of obstructions, too were also significant. Chronic intestinal obstruction of mechanical type and obstruction due to adynamic ileus did not reveal any significant difference from the control both preoperative and postoperatively. In the acute mechanical obstructions the levels were significantly higher in closed loop variety and also when the obstruction is complicated with ischaemic changes. However, the motility seems to be of Iesser importance in mechanical obstruction as the plasma Serotonin level were comparable irrespective of the presence of increased and diminished or absent bowel sounds. But the latter (acute mechanical obstruction with diminished or absent bowel sounds) had revealed significantly higher plasma level than in adynamic ileus. A clinical applicability and its relevance to differentiate between late cases of mechanical obstructions with absent bowel sounds and a true adynamic ileus has been emphasised.


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