IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1985 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded76    
    Comments [Add]    

Recommend this journal


Year : 1976  |  Volume : 8  |  Issue : 4  |  Page : 201-204

Effect of centrally administered glucagon on total blood cholesterol level in dogs

Correspondence Address:
K N Singh

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

"Glucago" administration by intracerebroventricular (I. C. V.) route resulted in lowering of total blood cholesterol level by 29.89% with a maximum decrease within 15 minutes. The hypocholesterolaemic effect of glucagon was not obtained in vasgotomized dogs, leading to the hypothesis that I. C. V. glucagon stimulates the vagal centre. In hepatectomized dogs. in which both vegi were intact, intraventricular administration of glucagon did of cause any hypocholesterolaemic effect and this suggests that centrally administered glucagon exerts its effect on liver through vagus. It is possible that I. C. V. administered glucagon stimulates the vagal centre which brings about a decrease in total blood cholesterol level by inhibiting the synthesis or its release from the liver.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow