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Year : 1976  |  Volume : 8  |  Issue : 3  |  Page : 181-185

Inhibitory effect of chlorpromazine on antibody synthesis

Correspondence Address:
K C Singhal

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Source of Support: None, Conflict of Interest: None

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Infraperitoneal administration of chlorpromazine in doses of 2.5, 5 and 12.5 mg/kg daily reduces antibody titres against the Salmonella typhi "H" and sheep red cell antigens in rabbits treated from seven days prior to the first immunizing dose. The reduction in the antibodies was found to be dose related. The reduction in antibody titres is not due to hypoproteinemia as serum protein levels were not altered following chlorpromazine administration.


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