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Year : 1976  |  Volume : 8  |  Issue : 2  |  Page : 141-144

Role of brain monoamines in pentylenetetrazol convulsions In mice

Correspondence Address:
S K Bhattacharya

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Source of Support: None, Conflict of Interest: None

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The role of brain dopamine in pentylenetetrazol (PTZ) induced clonic convulsions in albino mice was investigated by using drugs which selectively raise brain dopamine levels. dopamine receptor agonists and antagonists.PTZ convulsions were potenliated by drug treatments which selectively increase brain concentrations of dopamine and by dopamine receptor agonists, apomorphine and amphetamine. Haloperidol, a selective dopamine receptor antagonist. inhibited PTZ convulsions and apomorphine or amphetamine induced potentiation of PTZ. The results suggest that dopamine may have a role in PTZ induced clonic convulsions in mice.


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