IPSIndian Journal of Pharmacology
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Year : 1976  |  Volume : 8  |  Issue : 2  |  Page : 119-123

Modification of CNS excitatory activity of d-amphetamine by a-a-dipyridyl and reserpine in rats

Correspondence Address:
P Lauria

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The ambulation and rearing activities were tested on 'open field' in rats treated with amphetamine alone and in combination with ( -(-dipyridyl (DDP) and reserpine. The excitatory response of amphetamine in a doss of 2 mg/kg was not observed in rats pretreated with DDP or reserpine. Though the depressed activity in reserpinised rats was significantly antagonised by amphetamine, the values were still lower (P<0.001) than the control values. The data revealed the role of continuous norepinephrine synthesis in amphetamine excitatory response besides its release from the stores. The present work also indicates that dopamine is not directly responsible for amphetamine induced locomotor or stereotyped activity nor doer amphetamine stimulates adrenergic receptors directly to produce the excitatory response.


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