IPSIndian Journal of Pharmacology
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Year : 1975  |  Volume : 7  |  Issue : 4  |  Page : 47-50

Presenting papers: methods and forms

Correspondence Address:
P C Dandiya

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Source of Support: None, Conflict of Interest: None

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The role of 5-hydroxytryptamine (5HT) in hexobarbitone hypnosis has been investigated in albino rats and mice, by employing drugs, with well documented effects on 5HT turnover in brain and noting their interactions with hexobarbitone. 5HT synthesis inhibitor. p-chlorophenylalanine, end methysergide, a specific tryptaminargic receptor antagonist, inhibited hexobarbitone hypnosis and nialamide induced potentiation of hexobarbitone in rats but not in mice. The 5HT precursor, 5HTP, potentiated hexobarbitone action Only in rats and this potentiation was blocked by methysergide. The results indicate that hexobarbitone induced sleep in rats is 5HT mediated, while the same is not true in mice.


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