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Year : 1975  |  Volume : 7  |  Issue : 4  |  Page : 21-25

Screening of metal complexes for biological activity: Part I. Pharmacological investigations of some cobalt (II) oxalate complexes with substituted pyridines and quinoline.

Correspondence Address:
S K Bajpai

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Source of Support: None, Conflict of Interest: None

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Same oxalatoamine cobalt (II) complexes of the general formula COC2O4 (am), nH20 were prepared with a view to study their pharmacological activities. Compounds No. 1. 3 and 4 showed depressant effect on CNS, whereas compounds No. 5 and 6 were stimulants. Compounds No. 1, 2. 3 and 5. however. Possessed weak anti-inflammatory activity, whereas compounds No. 2 and 4 exhibited pronounced antipassive cutaneous anaphylaxis activity, The compounds studied neither showed any significant effect on CVS nor did they exhibit anti-arrhythmic and diuretic activity.


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