| RESEARCH PAPER
|Year : 1975 | Volume
| Issue : 4 | Page : 13-20
Studies on the pharmacological effects of extracts and total alkaloids of Tylophora indica
R Dhananjayan, C Gopalakrishnan, L Kameswaran
An alcoholic extract and the total alkaloids obtained from the leaves of the plant Tylophora lndica were studied for their pharmacological effects on various intact and isolated biological preparations. On the CNS, the extract and the total alkaloids produce depression in near lethal doses. On the CVS, the extract and the total alkaloids produce myocardial depression and fall of blood pressure in relatively large doses. On smooth muscles such as the ileum, uterus and tracheal ring chain of guinea pigs. rats and dogs, the drugs produce non-specific relaxation. The Contractile effects of histamine, acetylcholine and posterior pituitory extract are antagonised. The total alkaloids at a dose of 10 mg/kg (orally) prolong the survival rate of skin homografts in rats and increase the weight of adrenal glands.The probable mode of action in bronchial asthma is discussed.
Source of Support: None, Conflict of Interest: None