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Year : 1975  |  Volume : 7  |  Issue : 3  |  Page : 71-73

Inhibitory effect of carbamylcholine chloride on the response of the guinea pig atrium to histamine

Correspondence Address:
Kashani Monir

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Source of Support: None, Conflict of Interest: None

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In the absence and the presence of carbamylcholine (3x10-8M) and diphenhydramine (5x10-4M). dose response curves were constructed both for the inotropic and chronotropic effects of histamine. Carbamylcholine antagonised the effect of histamine in a noncompetitive manner and depressed the maximum response to histamine. Diphenhydramine did not change the response to histamine. The relation of the findings to change in C-AMP is discussed.


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