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 RESEARCH PAPER
Year : 1975  |  Volume : 7  |  Issue : 3  |  Page : 58-68

Studies on the role of brain monoamines in the antinociceptive action of morphine in albino rats



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S K Bhattacharya


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The effects of drugs known to influence brain monoamine turnover or block brain monoaminergic receptors, was observed on the antinociceptive action of morphine in albino rats. The antinociceptive action of morphine was inhibited by drugs depleting brain monoamines, decreasing 5-HT synthesis, displacing 5-HT from tryptaminergic neurones, 5-HT receptor antagonists and by agents enhancing brain dopamine concentrations. The antinociceptive action of a subanalgesic dose of morphine was potentiated by drugs enhancing 5-HT turnover. Reserpine induced inhibition of antinociceptive action of morphine was reversed by 5-HTP. The results suggest that, in albino rats, morphine analgesia is 5-HT dependent. with dopamine having an antagonistic effect.






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