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Year : 1975  |  Volume : 7  |  Issue : 3  |  Page : 38-43

Effect of amphetamine at various time intervals in open field situation in rats

Correspondence Address:
S K Patni

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Source of Support: None, Conflict of Interest: None

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The initial increase in locomotor activity followed by stereotypy due to amphetamine has been ascribed due to the activation of the noradrenergic and dopaminergic systems. respectively. In the Open Field situation, the present study revealed that pimozide significantly reduced both ambulatory and rearing (stereotypy) activity due to amphetamine while phenoxybenzamine significantly reduced only the ambulatory activity but not the rearing activity due to the same drug. It is, therefore. concluded that locomotor activity is due to the influence on noradrenergic and dopaminergic systems whereas rearing (stereotypy) is mediated through the dopaminergic system only.


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