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 RESEARCH PAPER
Year : 1975  |  Volume : 7  |  Issue : 1  |  Page : 22-26

Effects of neurohumors and some other drugs on the movement of Setaria cervi



Correspondence Address:
K C Singhal


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Setaria cervi, obtained from the peritoneal cavity of cattle, was suspended in 20 ml bath et 37o C in modified Ringer's solution. Recordings were taken on a slow moving kymograph. At least 15 min were allowed to establish normal activity and 10 min were taken es sufficient time to determine whether the test substance affected the movements of the worm. Fresh worm was used to test each dose of the drug even though the substance had no effect. Acetylcholine stimulated the movements of the worm. Eserine neither potentiated the action of acetylcholine nor had any effect of its own. The effect of acetylcholine was imitated by nicotine. xylocaine and procaine and was antagonized by GABA but not by d-tubocurarine, hexamethonium and atropine. Adrenaline. histamine, 5-hydroxy tryptamine, picrotoxin, strychnine. eserine and glycine had no effect on the movements of the worm. Penrobarbitone and GABA caused depression of the worm movements.






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