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Year : 1975  |  Volume : 7  |  Issue : 1  |  Page : 1-6

Effect of long term isoprenaline aerosols in guinea-pigs

Correspondence Address:
T Joseph

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Source of Support: None, Conflict of Interest: None

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Characteristic cardiac lesions, indicative of myocardial necrosis, were seen after isoprenaline aerosols in guinea-pigs. These changes were most marked in the one month treated group. and in animals that died during treatment. This was associated with an increase in chromaffin granules towards the periphery of the adrenal medulla with loss from the centre. These changes were minimal or absent in the three and six months treated group. The results obtained are discussed.


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