Adaptogenic effect of Morus alba on chronic footshock-induced stress in rats
Vandana S Nade1, Laxman A Kawale1, Rashmi A Naik1, Adhikrao V Yadav2
1 Department of Pharmacology, M.V.P. Samaj's College of Pharmacy, Gangapur Road, Nashik - 422002, India
2 Department of Pharmacology, Goa College of Pharmacy, Panaji - 403 001, India
Objective : The objective of the present study was to evaluate the adaptogenic property of the ethyl acetate-soluble fraction of methanol extract of Morus alba roots against a rat model of chronic stress (CS).
Materials and Methods : Rats were exposed to stress procedure for 21 days. The stress procedure was mild, unpredictable footshock, administered for 1 h once daily for 21 days. Rats were administered with the ethyl acetate soluble fraction of methanol extract of
M. alba roots (25, 50 and 100 mg/kg p.o) 1 h before footshock for 21 days and behavioral parameters were evaluated for cognitive dysfunction and depression using elevated plus maze and despair swim test, respectively. On day 21, rats were sacrificed immediately after stress and blood was collected for biochemical estimation. The adrenal gland and spleen were dissected for organ weight and the stomach was dissected for ulcer score.
Results : CS significantly induced cognitive deficit, mental depression and hyperglycemia and increased blood corticosterone levels, gastric ulcerations and adrenal gland weight, but decreased the splenic weight. Pre-treatments with the ethyl acetate soluble fraction of methanol extract of M. alba roots (25, 50 and 100 mg/kg, p.o.) significantly attenuated the CS-induced perturbations. Diazepam (1 mg/kg, p.o.) was used as the standard antistress drug.
Conclusion : The results indicate that M. alba possesses significant adaptogenic activity, indicating its possible clinical utility as an antistress agent.
Vandana S Nade
Department of Pharmacology, M.V.P. Samaj«SQ»s College of Pharmacy, Gangapur Road, Nashik - 422002
|How to cite this article:|
Nade VS, Kawale LA, Naik RA, Yadav AV. Adaptogenic effect of Morus alba on chronic footshock-induced stress in rats.Indian J Pharmacol 2009;41:246-251
|How to cite this URL:|
Nade VS, Kawale LA, Naik RA, Yadav AV. Adaptogenic effect of Morus alba on chronic footshock-induced stress in rats. Indian J Pharmacol [serial online] 2009 [cited 2013 May 25 ];41:246-251
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2009;volume=41;issue=6;spage=246;epage=251;aulast=Nade;type=0