| RESEARCH ARTICLE
|Year : 2010 | Volume
| Issue : 2 | Page : 90-94
Reproductive toxicity of sodium valproate in male rats
Laxminarayana Bairy1, Vijay Paul2, Yeshwanth Rao3
1 Department of Pharmacology, Kasturba Medical College, Manipal, India
2 Department of Anatomy, Maleka Manipal Medical College, Manipal, India
3 Department of Pharmacology, Maleka Manipal Medical College, Manipal, India
Objectives: To assess the effects of sodium valproate on rat sperm morphology, sperm count, motility, and histopathological changes in testis.
Materials and Methods: Male Wistar rats (12 week old) were treated with sodium valpraote and sacrificed at the end of 2 nd , 4 th , 5 th , 7 th , 10 th and 15 th week after the last exposure to sodium valproate. Epididymal sperm count, sperm motility, sperm morphology, and histopathology of testes were analyzed.
Results: Sperm count and sperm motility were decreased significantly by sodium valproate. The percentage of abnormal sperms increased in a dose-dependent manner. A histopathological study revealed that sodium valproate had caused sloughing of epithelial cells in testes.
Conclusion: Sodium valproate causes reversible change in sperm motility, sperm count, morphology, and cytoarchitecture of testes.
Department of Pharmacology, Kasturba Medical College, Manipal
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