| SHORT COMMUNICATION
|Year : 2002 | Volume
| Issue : 3 | Page : 198-201
The effect of captopril, prazosin and methyldopa on atherosclerotic plaque formation in hypercholesterolaemic rabbits
Husaini Fallah, M Manusuri Saber, Haghighi M Kavoli
1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs.
2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine.
3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.