IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 51 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1433    
    Printed47    
    Emailed0    
    PDF Downloaded111    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1976  |  Volume : 8  |  Issue : 4  |  Page : 221-226

Effect of histamine on chicken blood pressure and isolated smooth muscle preparations


,

Correspondence Address:
S S Yadav


Login to access the Email id


Get Permissions

Histamine response on chicken arterial blood pressure was characterized with a sharp fall followed by a rise. The depressor response of histamine in graded doses (1 to 8 (g/Kg. i. v.) was linear when plotted against its log doses. Blockade of histamine response on blood pressure with diphenhydramine was less in intensity and duration when compared with that of promethazine. Antihistaminic produced a marked and sustained rise in fowl blood pressure. Histamine in lower concentrations (2.5 x10-8 to 2 x 1 O-7 (g/ml) relaxed the isolated ileum of chick and this relaxation was blocked by pronethalol. Histamine in higher concentrations 4 x 1 O-7 to 8 x 1 O-7(g/ml) produced contractile response which was blocked both by promethazine and diphenhydramine. ED50 of histamine on chick ileum and oviduct, calculated from cumulative dose response curve, were 1 O-6M and 5 x 10-8 M respectively.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Medknow