IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1976  |  Volume : 8  |  Issue : 4  |  Page : 211-220

The effect of modification of autonomic activity on cardiac acetylcholine, tissue glycogen and blood sugar in albino rats and frogs


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S N Dube


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The effects of a number of autonomic agents and procedures which modify cholinergic and/or adrenergic activity were studied on cardiac acetylcholine, cardiac, skeletal muscle and hepatic glyeogen and blood sugar contents in albino rats and frogs. Tissue glycogen content was found to be higher, blood sugar much lower and cardiac acetylcholine slightly lower in frogs than in rats. Physostigmine treatment increased cardiac acetylcholine content in rats as well as in frogs. Atropine reduced cardiac acetylcholine contents in rats as well as in frogs. Vagotomy and pentolinium reduced cardiac acetylcholine content in rats and frogs, respectively. Modification of adrenergic activity did not affect cardiac acetylcholine content. Physostigmine in higher doses slightly increased ventricular glycogen in rats. Vagotomy reduced ventricular es well as hepatic glycogen in rats. Propranolol produced an increase in ventricular as well as muscle glycogen and decrease in blood sugar in rats but not in frogs. Adrenalectomy and 6-hydroxydopamine produced tissue glycogenolysis in rats. Pentolinium had variable effects in rats and frogs. The results indicate that cardiac acetylcholine content can be modified by altering parasympathetic activity and that adrenergic as well as cholinergic systems both effect tissue glycogen level.






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